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Assistant Professor, CLI
Specialty: Chemistry
Phone: 507-258-8207
Fax: 507-258-8066
Office: Broadway Hall
Email: muthy004@umn.edu
Blog: http://blog.lib.umn.edu/muthy004/orgoumr/teaching/why-organic-first/
Website: https://sites.google.com/a/umn.edu/university-of-minnesota-rochester---organic-chemistry-research/
Education
Ph.D., Chemistry, University of Hawaii, 1998
M.Sc., Chemistry, Osmania University, 1988
B.Sc., Chemistry and Mathematics, Osmania University, 1986
Background
I finished my undergraduate education in India and obtained a Ph.D in chemistry from the University of Hawaii. After postdoctoral stints at the Scripps Research Institute and the University of Illinois at Urbana-Champaign, I started my independent career at Queens College of the City University of New York in Sept. 2003. In Dec. 2008, I said aloha to New York City and moved to Rochester to be part of UMR.
Teaching and Research
I am passionate about organic chemistry and I enjoy teaching it. My research interests in chemical education and organic supramolecular chemistry are briefly described below.
Chemistry Education Research
Learning Space: In a collaborative study, Dr. Wei (now at Metropolitan State University) and I addressed the question of whether space matters in active learning. We investigated student learning in two different active learning classrooms. We used summative evaluations from midterm exams as well as formative assessment data from clickers to analyze student learning. You can read more about our work here.
Development of Interdisciplinary Curriculum Materials: I am interested in developing theme-based interdisciplinary curriculum materials and assessment of transfer of learning.
Anion Supramolecular Chemistry
Our primary focus is on developing a variety of molecular hosts for anions, particularly, chloride ions.
Representative Publications from Independent Work
Chloride Sensing via Suppression of Excited State Intramolecular Proton Transfer in Squaramides. M. Porel, V. Ramalingam , M. E. Domaradzki, V. G. Young, Jr., V. Ramamurthy and R. S. Muthyala Chemical Communications., 2013, 49(16) 1633-1635.
Does Space Matter? Impact of Classroom Space on Student Learning in an Organic-First Curriculum. R. S. Muthyala and W. Wei. J. Chem. Ed. 2013, 90 (1) 45-50. Published on the Web Nov. 26, 2012. DOI http://dx.doi.org/10.1021/ed3002122.
Carbonyl Groups as Molecular Valves to Regulate Chloride Binding to Squaramides. V. Ramalingam, M. E. Domaradzki, S. Jang and R. S. Muthyala. Organic Letters 2008, 10, 3315-3318.
Copper-Mediated Synthesis of Tertiary Diaryl Squaramides. V. Ramalingam, N. Bhagirath and R. S. Muthyala. J. Org. Chem. 2007, 72, 3976-3979
The Use of Squaric Acid as a Scaffold for Cofacial Phenyl Rings. R. S. Muthyala, G. Subramaniam, L., Todaro. Organic Letters 2004, 6, 4663-4665.
Representative Publications from Doctoral and Postdoctoral work
Equol, a Natural Estrogenic Metabolite from Soy Isoflavones: Convenient Preparation and Resolution of R- and S-Equols and Their Differing Binding and Biological Activity Through Estrogen Receptors Alpha and Beta. R. S. Muthyala, Y. H. Ju, S. Sheng, L. D. Williams, D. R. Doerge, B. S. Katzenellenbogen, W. G. Helferich, and J. A. Katzenellenbogen. Bioorg. Med. Chem. 2004, 12, 1559-1567.
Interaction of Exogenous Endocrine Active Substances with Nuclear Receptors. J. A. Katzenellenbogen and R. S. Muthyala. Pure and Applied Chem. 2003, 75, 2397-2403.
Bridged Bicyclic Cores Containing a 1,1-Diarylethylene Motif are High Affinity Subtype-Selective Ligands for the Estrogen Receptor. R. S. Muthyala, S. Sheng, K. E. Carlson, B. S. Katzenellenbogen and J. A. Katzenellenbogen. J. Med. Chem. 2003, 46, 1589-1602.
Correlation of Substituent Effects and Energy Levels of the Two Lowest Excited States of the Azulenic Chromophore. R. S. H. Liu, R. S. Muthyala, X.-S. Wang, A. E. Asato, P. Wang and C. Ye., Organic Letters, 2000, 2, 269-272.