Rajeev Muthyala, Ph.D.

Assistant Professor, CLI
+1 507 258 8207
(507) 258-8066
Broadway Hall


Ph.D., Chemistry, University of Hawaii, 1998
M.Sc., Chemistry, Osmania University, 1988 
B.Sc., Chemistry and Mathematics, Osmania University, 1986

Learning how chemistry impacts the social sciences and the humanities and vice versa has been an eye opening experience for me.


I finished my undergraduate education in India and obtained a Ph.D in chemistry from the University of Hawaii. After postdoctoralstints at the Scripps Research Institute and the University of Illinois at Urbana-Champaign, I started my independent career at Queens College of the City University of New York in Sept. 2003. In Dec. 2008, I said aloha to New York City and moved to Rochester to be part of UMR.

Teaching and Research

I am passionate about organic chemistry and I enjoy teaching it. My research interests in chemical education and organic supramolecular chemistry are briefly described below.

Chemistry Education Research

Design and Assessment of FOCAL:  Inspired by Prof. David Reingold’s Bioorganic First curriculum at Juniata College, I designed FOCAL (Freshman Organic Chemistry via Active Learning) using research on how students learn and emphasizing a mechanistic approach to teaching organic chemistry. A preliminary assessment of student learning in FOCAL was presented at the Biennial Conference on Chemical Education at Penn State University in July 2012.

Learning Space: In a collaborative study, Dr. Wei (now at Metropolitan State University) and I addressed the question of whether space matters in active learning. We investigated student learning in two different active learning classrooms. We used summative evaluations from midterm exams as well as formative assessment data from clickers to analyze student learning. You can read more about our work here.

Development of Interdisciplinary Curriculum Materials: I am interested in developing theme-based interdisciplinary curriculum materials and assessment of transfer of learning.

Anion Supramolecular Chemistry

Our primary focus is on developing a variety of molecular hosts for anions, particularly, chloride ions.

Representative Publications from Independent Work

Chloride Sensing via Suppression of Excited State Intramolecular Proton Transfer in Squaramides. M. Porel, V. Ramalingam , M. E. Domaradzki, V. G. Young, Jr., V. Ramamurthy and R. S. Muthyala Chemical Communications., 2013, 49(16) 1633-1635.

Does Space Matter? Impact of Classroom Space on Student Learning in an Organic-First Curriculum. R. S. Muthyala and W. Wei. J. Chem. Ed. 2013, 90 (1) 45-50. Published on the Web Nov. 26, 2012. DOI

Carbonyl Groups as Molecular Valves to Regulate Chloride Binding to Squaramides. V. Ramalingam, M. E. Domaradzki, S. Jang and R. S. Muthyala. Organic Letters 2008, 10, 3315-3318.

Copper-Mediated Synthesis of Tertiary Diaryl Squaramides. V. Ramalingam, N. Bhagirath and R. S. Muthyala. J. Org. Chem. 2007, 72, 3976-3979

The Use of Squaric Acid as a Scaffold for Cofacial Phenyl Rings. R. S. Muthyala, G. Subramaniam, L., Todaro. Organic Letters2004, 6, 4663-4665.

Representative Publications from Doctoral and Postdoctoral work 

Equol, a Natural Estrogenic Metabolite from Soy Isoflavones: Convenient Preparation and Resolution of R- and S-Equols and Their Differing Binding and Biological Activity Through Estrogen Receptors Alpha and Beta. R. S. Muthyala, Y. H. Ju, S. Sheng, L. D. Williams, D. R. Doerge, B. S. Katzenellenbogen, W. G. Helferich, and J. A. Katzenellenbogen. Bioorg. Med. Chem. 2004, 12, 1559-1567.

Interaction of Exogenous Endocrine Active Substances with Nuclear Receptors. J. A. Katzenellenbogen and R. S. Muthyala. Pure and Applied Chem. 2003, 75, 2397-2403.

Bridged Bicyclic Cores Containing a 1,1-Diarylethylene Motif are High Affinity Subtype-Selective Ligands for the Estrogen Receptor. R. S. Muthyala, S. Sheng, K. E. Carlson, B. S. Katzenellenbogen and J. A. Katzenellenbogen. J. Med. Chem. 2003, 46,1589-1602.

Correlation of Substituent Effects and Energy Levels of the Two Lowest Excited States of the Azulenic Chromophore. R. S. H. Liu,R. S. Muthyala, X.-S. Wang, A. E. Asato, P. Wang and C. Ye., Organic Letters, 2000, 2, 269-272.